Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice.
نویسندگان
چکیده
s of the Fifth International Complement Workshop, Hotel Del Coronado, Coronado, California, February 23-25. 1973 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 286 NUMBZR 2, AUGUST 1973
منابع مشابه
The Effect of Polyinosinic-Polycytidylic Acid on the Immune Response of Mice to Antigenically Distinct Tumors1
Polyinosinic-polycytidylic acid temporarily inhibits the growth rate of visible, transplanted tumors of both chemical (methylcholanthrene-induced fibrosarcomas) and viral (murine poly orna) origin with nearly equal facility. This effect is dose related and is associated with lymphopenia and death at high doses or following prolonged administration. Polyinosinicpolycytidylic acid produces a vari...
متن کاملThe effect of polyinosinic-polycytidylic acid on the immune response of mice to antigenically distinct tumors.
Polyinosinic-polycytidylic acid temporarily inhibits the growth rate of visible, transplanted tumors of both chemical (methylcholanthrene-induced fibrosarcomas) and viral (murine poly orna) origin with nearly equal facility. This effect is dose related and is associated with lymphopenia and death at high doses or following prolonged administration. Polyinosinicpolycytidylic acid produces a vari...
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One of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. In this study the effect of the male hormone 5a-DHT on cytokine release by peritoneal macrophages (mΦ) of male and female NZB/BALBc mice was investigated. Macrophages from male mice activated with LPS produced a greater amount of IL-1β (21.8%) (p<0.05) and IL-...
متن کاملProtective Effect of Immunization with Polyinosinic • Polycytidylic Acid Complexed with Methylated Bovine Serum Albumin against Friend Leukemia Virus in Mice'
Mice hyperimmunized with polyinosinic . polycytidylic acid complexed with methylated bovine serum albumin were protected against challenge with Friend leukemia virus. The virus was inoculated at the time when anti bodies reacting to the polynucleotide structure had reached an appreciable level. A sparing effect of approximately 1.5 logs in infectivity was afforded the immunized mice. Our result...
متن کاملDetection of Pre-Malifnant B-1 Cells in NZB Mice with a Re-stricted CDR3/DFL16 Region
The relationship between the immunoglobulin (Ig) nucleotide sequence and the ability of a B cell to develop into a malignant cell was studied in a subset of B cells, B-1 cells. B-1 cells become malignant in chronic lymphocytic leukemia (CLL) and are responsible for the production of "natural autoantibodies". The autoimmune NZB mouse has been known as a human malignancy and CLL model, because ...
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ورودعنوان ژورنال:
- Journal of immunology
دوره 111 1 شماره
صفحات -
تاریخ انتشار 1973